麻豆av资源_日本三级一区_www.狠狠艹_国产精妇在线观看第一区_成人性生交大片免费看中国A片_日本一本久久

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
麻豆四区,超碰公开免费,色悠久久久久久久综合网伊人
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-KALRN/PE Conjugated antibody (bs-11861R-PE)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-11861R-PE
英文名稱 Rabbit Anti-KALRN/PE Conjugated antibody
中文名稱 PE標記的舞蹈癥相關(guān)蛋白KALRN抗體
別    名 Duo; FLJ16443; HAPIP; Huntingtin associated protein interacting protein (duo) ; Huntingtin-associated protein-interacting protein; Kalirin (isoform 2); Kalirin; KALRN ; KALRN_HUMAN ; Protein Duo; RhoGEF kinase; Serine/threonine kinase with Dbl and pleckstrin homology domains ; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain; TRAD.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  生長因子和激素  激酶和磷酸酶  細胞膜受體  G蛋白偶聯(lián)受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Horse, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 340kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KALRN/Duo
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
HAP1 (huntingtin-associated protein 1) binds to huntingtin. Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, the gene encodes a version of huntingtin that leads to Huntington’s disease (HD). The ability of HAP1 to bind to huntingtin is enhanced by an expanded polyglutamine repeat region. HAP1 shows neuronal localization and moves with huntingtin in nerve fibers. HAP1 is primarily expressed in brain tissue, with greater expression in the olfactory bulb and brain stem. Mouse HAP1 is localized to membrane-bound organelles including large endosomes, tubulovesicular structures and budding vesicles in neurons. Duo, also designated huntingtin-associated protein interacting protein or HAPIP, binds Huntingtin-associated protein 1 (HAP1) and may have a role in vesicle trafficking and cytoskeletal function.

Function:
Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.

Subunit:
Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1) (By similarity). Interacts with FASLG.

Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with the cytoskeleton.

Tissue Specificity:
Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle.

Post-translational modifications:
Autophosphorylated.

DISEASE:
Genetic variation in KALRN is associated with susceptibility to coronary heart disease type 5 (CHDS5) [MIM:608901]. CHD is the leading cause of death and disability worldwide. CHD is multifactorial disease with a strong genetic component. Classic epidemiologic studies have revealed many risk factors for CHD, including age, sex, hypertension, dyslipidemia, diabetes mellitus, smoking, and physical inactivity.

Similarity:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Contains 1 CRAL-TRIO domain.
Contains 2 DH (DBL-homology) domains.
Contains 1 fibronectin type-III domain.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 2 PH domains.
Contains 1 protein kinase domain.
Contains 2 SH3 domains. Contains 5 spectrin repeats.

Database links:

Entrez Gene: 8997 Human

Entrez Gene: 545156 Mouse

Entrez Gene: 84009 Rat

Omim: 604605 Human

SwissProt: O60229 Human

SwissProt: A2CG49 Mouse

SwissProt: P97924 Rat

Unigene: 8004 Human

Unigene: 353103 Mouse

Unigene: 450612 Mouse

Unigene: 82274 Mouse

Unigene: 87882 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 m.jywcc.com 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 国产三极片 | 蜜桃免费一区二区三区 | 无码天堂亚洲国产AV麻豆 | 欧美一日本 | 91视频啪啪 | 国产丝袜在线观看一区 | 99re6这里只有精品视频在线观看 | 久草老司机 | 性高湖久久久久久久久免费 | 97色国产| 国产在线不卡2005 | 99热官网 | 无码黄片在线播放观看 | 无码人妻精品一区二区三区东京热 | 97精品视频在线 | 色秘?乱码一区二区三区唱戏 | 少妇多水XXXX色情免费 | 日本a级片免费观看 | 欧美日韩无套内射另类 | xxxx亚洲| 亚洲欧美精 | 久久久国产一区二区三区四区 | 三级理论日韩欧美 | 亚洲嫩模一区二区三区 | 好男人好资源在线观看免费视频 | 亚洲国产欧美在线观看片不卡 | 欧洲性XXXX免费视频在线观看 | 国产精品69久久久久 | 国内精品久久久久久久999 | 把女邻居弄到潮喷的性经历 | 精品中文日本三级 | 日韩精品在线观看一区二区 | 公和我做好爽添厨房在线观看 | 开心五月丁香花综合网 | 天干天干天啪啪夜爽爽AV | 久久精品国产一区二区三区肥胖 | 国产高清一级毛片在线人 | 他扒开我奶罩揉吮我奶头视频 | 国产精品一二三 | 老司机精品在线观看 | 美女国产精品 |